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Presentations |
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Research Interests Ìý |
As a student in the Medical Scientist Training Program (MSTP) I am interested in contributing to the understanding of the interplay between cells of the immune system and disease-causing agents, and how it ultimately affects clinical outcomes. During my undergraduate training at the University of Massachusetts Amherst, I examined the kinetic refolding properties of the metastable protein A1AT. After graduation, I spent two years at NIDDK at the NIH, seeking to elucidate, through application of genetic and biochemical techniques inÌýSaccharomyces cerevisiae,Ìýthe mechanisms by which prion formation is prevented and controlled.Ìý Specifically, I identified genetic relationships between a novel component of the yeast anti-prion system and other known and unknown actors previously found. |
| Publications |
Wickner, R.B., Edskes, H.K., Son, M., Wu, S., andÌýNiznikiewicz, M. (2023). Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems. In Prions and Diseases (pp. 599-618). Cham: Springer International Publishing. Wickner, R.B., Edskes, H.K., Son, M., Wu, S., andÌýNiznikiewicz M. (2021). Innate immunity to prions: anti-prion systems turn a tsunami of prions into a slow drip. Current Genetics, doi: 10.1007/s00294-021-01203-1. Epub ahead of print. PMID: 34319422. Wickner R.B., Edskes H.K., Son, M., Wu, S., andÌýNiznikiewicz, M. (2020). How Do Yeast Cells Contend with Prions? International Journal of Molecular SciencesÌý21(13):4742. https://doi.org/10.3390/ijms21134742 |
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Honors and Awards |
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