Zhishan Wang, MD, PhD
Zhishan Wang, MD, PhD
Professor of Research
Department of Pathology
Stony Brook Cancer Center
MART 7M-0836
631-216-2703
Zhishan.Wang@stonybrookmedicine.edu
Research Interest:ÌýEnvironmental carcinogenesis, Cancer biology and Cancer therapy.
Research Summary: Metal carcinogen exposure through ingestion or inhalation causes lung cancer, the underlying mechanism has not been well understood. The research in my laboratory investigates the mechanism of lung cancer resulting from exposure to carcinogenic metals alone or in combination with other chemical carcinogens using cell culture and genetically modified mouse models. We perform mechanistic studies in following three areas: (1) investigate the epigenetic regulation of metal carcinogen exposure-induced cancer stem cell (CSC)-like property; (2) characterize the microenvironment of lung tumors resulting from metal carcinogen exposure. ÌýIntact immune surveillance is critical to prevent cancer development and progression. We study the mechanism of how metal carcinogen exposure-caused epigenetic changes reshape tumor microenvironment, specifically immune cell reprograming, therefore, to reduce immune surveillance and promote carcinogenesis; and (3) determine metal carcinogen exposure-caused microbiota change and its role in carcinogenesis. Better understanding of the mechanism of carcinogenesis will allow us to develop mechanism-based strategies to efficiently prevent and treat cancer.
Graduate student positions are available to study the mechanism of carcinogenesis.
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Bachelor of Medicine ÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌý MDÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý1986
Ìý
Master of Environmental HealthÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý ÌýMSÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý 1989
Environmental Microbiology, Tongji China
Ìý
Institution and LocationÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý PhDÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý 1998ÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌý
Environmental Health/ Molecular Biology,
Tongji Medical University, Beijing China
Ìý
MD Certification, USA Educational Commission
For Foreign Medical GraduatesÌý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý Ìý ÌýMD ÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌý 2007
Residency and Fellowship Training
Ìý1999-2000 Postdoctoral Research Fellow, Department of Genetics, Emory
2000-2001 Postdoctoral Research Fellow, Department of Medicine, University of Alabama at Birmingham
2002-2003 Postdoctoral Research Fellow, Lankenau Institute for Medical Research, Jefferson Health System, Wynnewood, PA
Current and Previous Appointments
2003-2007 Research Specialist, Department of Medicine, University of Pennsylvania School of Medicine
2007-2015 Research Associate, Department of Physiology, Michigan State University
2015-2016 Assistant Professor, Department of Physiology, Michigan State University
2016-2021 Assistant Professor, Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky
2021-2022 Associate Professor, Division of Cancer Biology, Department of Medicine, MetroHealth Medical Center, Cleveland, OH